Upon taking her vows to become a nun, Sister Sarah is abused, brainwashed and drugged into submission by the corrupt clergy. On the verge of death from a lethal dose of drugs, Sister Sarah receives a message from God telling her to take vengeance on all those who did her wrong. Armed with God’s will and an arsenal of big guns, she dispenses Judgment Day on her former tormentors. When the church hires the merciless motorcycle gang the “Los Muertos” to track down and kill her they soon realize that this sister is one bad mother.

The film opens on a water-skiing accident – a girl (Délie) drives a speedboat and pulls a young man (Stan). They are both challenging their own limits when a crash occurs… Stan wakes up from a coma after this serious accident, to find out that genealogists are looking for an individual whose identity corresponds to his. Instead of asking himself questions about this testamentary filiation, he subscribes for Professor Starkov’s legacy, and embarks for the country of Las Estrellas… Purging odyssey where intuition and telepathy accelerates the journey in time. Dharma Guns revisits the myth of Orpheus and Eurydice fighting with the tyranny of Time-God…

Six unrelated people must push through their past and the mob underworld to discover what has controlled each of them all these years. Sex, Drugs, Guns and God have created a series of events which will leave each of them changed forever.