After an experimental drug trial goes awry, the test subjects face a terrifying side effect: if you fall asleep you die. Trapped in an isolated facility, panic ensues as they try to escape and somehow stay awake.

Harvey Keitel plays Penfield Gruber, a once great scientist, reduced to managing a sleazy hotel. Gruber monitors the daily comings and goings of his tenants, mainly for his own interest, until underworld figures ask him to spy on a suspected double-crosser. While watching the man, Gruber overhears a murder plot.

A blind, but deadly, gunman, is hired to escort fifty mail order brides to their miner husbands. His business partners double cross him, selling the women to bandit Domingo. Blindman heads into Mexico in pursuit.

One moment some 80 people are walking on a big city street. Suddenly a blinding light appears that transports them to a very peculiar racing course. A voice sounds in everybody’s head : “The school, the house and the prison are safe. Follow the arrows or you will die. Stay on the path or you will die. If you’re doubled twice, you will die. Do not touch the grass or you will die. Race or die.” Whether you’re rich or poor, old or young, blind, strong, handicapped, courageous or a coward; the rules make no distinction. There can be only one winner !

Mob assassin Jeffrey is no ordinary hired gun; the best in his business, he views his chosen profession as a calling rather than simply a job. So, when beautiful nightclub chanteuse Jennie is blinded in the crossfire of his most recent hit, Jeffrey chooses to retire after one last job to pay for his unintended victim’s sight-restoring operation. But when Jeffrey is double-crossed, he reluctantly joins forces with a rogue policeman to make things right.

Charlie, a down-on-his-luck loner, crosses paths with a blind homeless man who is his exact double. Perplexed and intrigued by the discovery, Charlie invites the man into his life.