After narrowly escaping a bizarre accident, a troubled teenager is plagued by visions of a large bunny rabbit that manipulates him to commit a series of crimes.

S. Darko follows Samantha Darko, the younger sister of Donnie, the protagonist of Donnie Darko, and her friend Corey. On their way to California, their car breaks down, forcing them to wait in a small town until it is fixed. While there, Samantha begins to have dreams that warn her of the end of the universe.