Years after the events of Noxious, our protagonist is on the run and her past is catching up with her.
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Alison Wynn is an amateur triathlete who convinces Dr. Laura Stevens, a controversial peak-performance trainer, to take her on as a client. Together they embark on a rigorous program combining cutting-edge physical training with experimental hypnotherapy in an effort to render Alison more competitive. Pushed to her limits and forced to explore the painful repressed memories of her mother’s suicide, Dr. Stevens’ punishing regimen helps Alison post impressive gains and break through her own glass ceiling; but at what cost? Alison’s work and family life with her husband and daughter suffer but no sacrifice seems too great to satisfy Laura’s escalating demands. In fact Laura will do whatever it takes to have Alison all to herself. As Alison runs directly into Laura’s sinister psychological trap, it’s up to Alison’s daughter to help her mother see through the deception before they lose her forever.
When motocross and heavy metal obsessed, 13-year-old Jacob’s delinquent behavior forces CPS to place his little brother Wes with his aunt, Jacob and his emotionally absent father must finally take responsibility for their actions and each other in order to bring Wes home.
Sheriff Church (Robert De Niro) and Detective Zeppelin strive to keep the peace in their rough town, where residents’ only two interests are the church or oxycodone. Newly engaged Shelby John (Jack Huston) and Ruby Red want a fresh start. They decide to have a family together and get clean, with the support of Peter, Ruby’s brother-in-law (John Malkovich). However Shelby discovers his beloved Ruby dead on their porch before she could fulfill her final wish: to be baptized in the river and washed away from her past sins. Filled with fiery rage, Shelby embarks on a vengeful killing spree to right all the wrong done to Ruby by every link in the drug dealing chain. Armed with nothing but adrenaline and a nail gun, Shelby picks off dealers and junkies one by one until he gets to the top. Sheriff Church and Detective Zeppelin must race against the clock to put an end to Shelby’s vigilante justice before his fight with the crime lord Coyote (Quavo) turns the entire town into a bloodbath.
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